Too fat? Take two aloe vera capsules at breakfast and another two with lunch. Do that for two months and guess what? You lose almost a kilo of fat and gain half a kilo of lean body mass. At least, you will if you react to aloe vera as well as the subjects did when Ho-Chun Choi and Seok-Joong Kim – both working at Seoul National University Hospital in South Korea – did their experiment.
Aloe vera is a succulent plant which people have been using to make cosmetic products for thousands of years. These products, if you’re not allergic to the plant, are safe. Extracts of aloe vera are also increasingly found in food and supplements, especially since the rise in popularity of functional foods.
Toxicologists are not a hundred percent happy with this: aloe vera contains a laxative substance, aloin, which is an anthraquinone [first structural formula above at right]. The FDA decided in 2002 that this substance could not be used in laxatives while its safety cannot be guaranteed. [Federal Register: May 9, 2002 (Volume 67, Number 90)] Aloin may be carcinogenic, according to the FDA.
We don’t know whether this substance is present in the aloe vera supplements that the Koreans tested. Those capsules contained Aloe QDM complex: 147 mg processed aloe vera gel and 3 mg aloesin [second structural formula above] per capsule. The potentially risky aloin is usually found in aloe vera gel.
The extracts that the Koreans used were produced by Univera, a manufacturer of aloe vera products. [univera.com] Univera sponsored the study.
The Koreans used 120 subjects in their study, all of whom were not only obese, but also had stage-1 type-2 diabetes. Half of them were given a placebo for 8 weeks; the other half were given 4 capsules containing the aloe vera extract every day.
In the 8 weeks that the experiment lasted, the subjects that had been given aloe vera lost 0.9 kg fat and gained 0.6 kg lean body mass.
The HOMA-IR, a measure of insulin insensitivity, went down in the aloe vera users. The fasting glucose level [FBG] also decreased. This effect was already known from animal studies. [Biol Pharm Bull. 2006 Jul;29(7):1418-22.] [Phytother Res. 2001 Mar;15(2):157-61.]
The Koreans are not sure exactly how the supplement works. Reading between the lines, it looks as though they think aloe vera might improve body composition by making cells more sensitive to insulin.
“Aloe QDM complex reduced body weight and body fat mass and improved insulin sensitivity in obese patients with prediabetic and early untreated diabetes”, the Koreans concluded. “Studies are needed to evaluate the effects of the long-term use of the Aloe QDM complex in patients with overt diabetes.”
It might be a good idea to stay clear of slimming supplements that contain aloe vera until it’s certain that they are safe. Like the FDA in 2002, toxicologists at the National Center for Toxicological Research in the US also said in 2006 that they were not completely sure about the reliability of food and supplements containing aloe vera. Rats that are fed aloe vera extracts in their drinking water have been known to develop cancer. [J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2006 Apr;24(1):103-54.]
Metabolic effects of aloe vera gel complex in obese prediabetes and early non-treated diabetic patients: randomized controlled trial.
The metabolic effects of an aloe vera gel complex (Aloe QDM complex) on people with prediabetes or early diabetes mellitus (DM) are unknown. The goal of this study was to determine the effects of Aloe QDM complex on body weight, body fat mass (BFM), fasting blood glucose (FBG), fasting serum insulin, and Homeostasis Model of Assessment – Insulin Resistance (HOMA-IR) in obese individuals with prediabetes or early DM who were not on diabetes medications.
Participants (n = 136) were randomly assigned to an intervention or a control group and evaluated at baseline and at 4 and 8 wk.
The study lost six participants in the control group and eight in the intervention group. At 8 wk, body weight (P = 0.02) and BFM (P = 0.03) were significantly lower in the intervention group. At 4 wk, serum insulin level (P = 0.04) and HOMA-IR (P = 0.047) were lower in the intervention group; they also were lower at 8 wk but with borderline significance (P = 0.09; P = 0.08, respectively). At 8 wk, FBG tended to decrease in the intervention group (P = 0.02), but the between-group difference was not significant (P = 0.16).
In obese individuals with prediabetes or early untreated DM, Aloe QDM complex reduced body weight, BFM, and insulin resistance.
Copyright © 2013 Elsevier Inc. All rights reserved.
PMID: 23735317 DOI: 10.1016/j.nut.2013.02.015